| NCTR presents at FDA Grand Rounds: Studies of SARS-CoV-2 NSP1 and Envelope Protein Date: Thursday, March 11, 2021 Time: 12:00 pm–1:00 pm EST Webcast Only REGISTER NOW and get more information. About the Speaker: Marli Azevedo, Ph.D., Research Biologist, Division of Microbiology, NCTR Dr. Marli Azevedo studied pharmacy and clinical biochemistry at the College of Pharmacy, Brazil. She earned an M.S. in tropical medicine with a focus in virology studying diarrheal diseases affecting HIV patients. She earned a Ph.D. in virus immunology at The Ohio State University, focusing on vaccine design and enteric virus pathogenesis, where she then trained as a postdoctoral fellow and worked as a research scientist and adjunct assistant professor. In 2009, she joined the Division of Microbiology at NCTR. Presentation: - Describe the SARS-CoV-2 genome organization and its comparison with other Human Coronaviruses.
- Give a brief overview of SARS-CoV-2 replication cycle.
- Give a brief overview of SARS-CoV-2 non-structural proteins and their known functions.
- Provide an in depth overview of NSP1 and envelope protein functions.
- Describe the effects of NSP1, envelope protein and nucleocapsid expression in HEK293T cells.
- Explain the role of NSP1 and envelope protein on the intracellular calcium modulation.
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